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This may be of clinical significance especially for medications with a narrow therapeutic index, where small differences in blood concentration might lead to therapeutic failure or adverse reactions

Pooled mean follow-up on-treatment for semaglutide users was 193 days (median 157 days, interquartile range (IQR) 85 to 331 days) and for sitagliptin users 195 days (median 160 days, IQR 95 to 322 days)

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However, many Type 2 diabetics will not achieve sufficient control of their blood sugar on metformin alone and will be placed on one or more additional therapies, as outlined in the previously mentioned treatment guidelines

In addition, a SEAP (secreted embryonic alkaline phosphatase) reporter gene under the control of a minimal promoter fused to nine cAMP response elements (CRE) was introduced

(Refer to Table 1 for details of clinical trials evaluating GLP-1 and insulin)