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Large cardiovascular outcome trials involving over 60,000 patients found no statistically significant increase in pancreatitis rates with GLP-1 agonists versus placebo

In vitro metformin anti-neoplastic activity in epithelial ovarian cancer

Side effects from weeks 2-3 typically diminish

Mechanistically, metformin inhibits intestinal glucose absorption (Wilcock and Bailey, 199)

Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype

Notably, elective terminations were higher (18%) in the GLP-1 group, driven largely by patient anxiety rather than medical necessity