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After propensity score matching, the final cohort included 86 632 adults (43 317 individuals taking GLP-1RAs and 43 315 matched nonusers)

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Because statin efficacy depends on sustained hepatic HMG-CoA reductase inhibition (an AUC-driven effect, not a Cmax-driven effect), the interaction is not clinically meaningful

Additionally, the interaction between substance abuse and depression may worsen depressive symptoms and its prognosis, leading to a vicious cycle that further complicates metabolic health [48]

Introduction Managing weight while navigating chronic digestive issues can feel like a delicate balancing act