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The survival benefit was more pronounced in younger people and those with cardiometabolic comorbidities, highlighting the need for a careful riskbenefit evaluation when prescribing GLP-1 RAs in high-risk individuals.

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Data on hepatic fibrosis are limited or inconclusive, although some studies reported improvement in indices of fibrosis or prevention of fibrosis initiation or reduction of collagen deposition

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Triple receptor agonist: GLP-3R, also identified in scientific literature as LY-3437943, is an investigational peptide classified as a triple-receptor agonist