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Older patients, conversely, were less likely to discontinue

The SURMOUNT-5 trial (Rosenstock et al., Lancet 2025) showed 24.2% mean weight loss at 48 weeks, compared to 15.7% for semaglutide 2.4 mg

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For practices and PCNs, the tirzepatide vs semaglutide question is best answered through eligibility, safety and pathway suitability rather than weight loss data alone

One potential solution might lie at the Pennington Biomedical Research Center, where Dr

The 2022 New England Journal of Medicine study showing effectiveness of Wegovy at preventing Major Adverse Cardiovascular Events (MACE) required 100 people to be treated for 3 years to prevent one MACE event