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78 National Institute of Diabetes and Digestive and Kidney Diseases

Do not use ZEPBOUND if: you or any of your family have ever had a type of thyroid cancer called MTC or if you have an endocrine system condition called MEN 2

For example, patients with specific GLP1R variants may experience robust appetite suppression at lower doses, while others require closer to maximum doses to feel the medication's effects

This genetic insight helps your provider anticipate whether you may benefit from rapid dose escalation or a slower titration, all delivered through the standard once-weekly injection schedule

This approach is considered an off-label use

Brains were snap-frozen in isopentane and the OB ( n = 10) or LH ( n = 8) was cut into 18 or 30 m-thick sections respectively, using a cryostat (Leica Biosystems)