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Side effects and patient compliance are important, with as many as 10% discontinuing treatment because of them

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Eligible participants were required to have no history with drug use, psychiatric or neurological illnesses, heart conditions, high blood pressure, pregnancy and glaucoma

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The gene therapy is specifically approved for those patients who currently use factor IX (FIX) prophylaxis therapy, or have current or historical life-threatening hemorrhage, or repeated, serious spontaneous bleeding episodes and do not have neutralizing antibodies to the adeno-associated virus serotype Rh74var (AAVRh74var) capsid

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doi: 10.2337/dc24-1533

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