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GLP-1 medications like Wegovy, Semaglutide, and Ozempic have received significant attention because of their impressive results in aiding weight loss

The authors reported statistically significant mean reductions in body weight from baseline across the retatrutide dose groups relative to placebo, with gastrointestinal adverse events the most frequently reported findings, consistent with the incretin-agonist class

34 36 Consequently, these practical administration challenges and potential for adverse events likely lead to greater caution among health care providers when prescribing GLP-1 RAs to older patients

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This presumably reflects the ability of long-acting GLP-1 analogs to enter the brain at areas with an incomplete BBB, such as the median eminence

Relationship between measures of adiposity, arterial inflammation, and subsequent cardiovascular events