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DiMarchi had just left the company and become a professor of chemistry at Indiana University, and also wanted to develop obesity treatments that combine multiple drug targets

320 These observations were confirmed in ob/ob mice and high-fat-fed mice when they were treated with a GIPR antagonist, and also in mice lacking GIP-secreting K cells, confirming the important role of GIP in fat accumulation

Multiple studies demonstrate beneficial effects on food cravings and disordered eating

Antiemetics such as ondansetron, dexamethasone, aprepitant, and diphenhydramine should be considered

K.PlutzkyJ.ArodaV

doi: 10.1038/s41574-021-00507-z