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Here is more information on the Functional and Clinical Significance of the 24-Hour Rhythm of Circulating corticosteroid hormones.

Avoiding severe calorie restriction: GLP-1 medications should reduce hunger, not encourage near-starvation

Inform your healthcare provider if you experience frequent episodes of low blood glucose

Healthcare professionals should: Provide clear safety-netting advice about nutritional concerns Encourage maintenance of a balanced, nutrient-rich diet Consider dietitian referral for vulnerable patients Investigate and treat confirmed iron deficiency appropriately Follow NICE and BSG guidance for investigation of iron deficiency anaemia Review the risk-benefit profile of continuing Wegovy if nutritional deficiencies prove difficult to manage If patients suspect they are experiencing side effects from Wegovy, they or their healthcare professional can report these through the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)

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"This is one of the acknowledged limitations of the study, as we didn't have access to biopsies of the intestines of these individuals to assess the amount and activity of serotonin-producing cells," concluded Ferraz-Bannitz