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Additionally, we compare different GLP-1 receptor agonists and discusses promising new drugs in the pipeline

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The median time to reach maximum plasma concentration (Tmax) varies: 14 h for sitagliptin, 24 h for saxagliptin, 1.7 h for vildagliptin, 1.5 h for linagliptin, 1 h for teneligliptin, and 12 h for alogliptin

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[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Kushner R.F., Calanna S., Davies M., Dicker D., Garvey W.T., Goldman B

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The biological activity can be assessed using a colorimetric bioassay consisting of the engineered cell line HEK-Blue GLP-1 expressing the GLP-1R together with a CREB-inducible SEAP reporter gene (see figure)

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