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Intermittent hypoxia appears to be a key mediator, with greater severity of obstructive sleep apnoea correlating with more pronounced spermatogenic impairment

Its normal to regain some weight after treatment

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This is significant because it is the natural site of action of the GLP1-RAs and most relevant to their uses in diabetes and appetite control

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Additionally, these medications cause delayed gastric emptying, particularly in the early stages of treatment, which contributes to feelings of fullness but tends to attenuate over time with continued use