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rather, it serves as a powerful tool that enables patients to adhere to a lower-calorie diet without the constant distraction of food cravings

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This analytical approach proves particularly valuable for detecting subtle modifications including oxidation, deamidation, or other chemical changes that might not significantly affect HPLC retention behavior but could impact biological activity

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26 In a review of nine cases of EDKA in both T1DM and T2DM patients, four patients in the T1DM subset had recurrent EDKA when restarted on SGLT2i and one patient presented with ketonuria 48 hours after discontinuation of canagliflozin

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