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Some researchers have even reported cases of severe thiamine (vitamin B1) deficiency leading to Wernicke encephalopathy, a potentially dangerous neurological condition

GLP-1 induces barrier protective expression in Brunners Glands and regulates colonic inflammation

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Patients with longstanding diabetes and established autonomic neuropathy face elevated baseline gastroparesis risk independent of GLP-1 use, making causality attribution particularly challenging in this population

Crucially, none of these studies utilized adjudicated endoscopic assessments, meaning true reparative mucosal healing could not be verified (101, 103)

MHRA finds evidence does not support a link between Glucagon-Like Peptide-1 (GLP-1) receptor agonists and suicidal and self-injurious thoughts and actions Following a thorough review, the Medicines and Healthcare products Regulatory Agency (MHRA) has concluded that the available evidence does not establish a causal relationship between Glucagon-Like Peptide-1 (GLP-1) receptor agonists and suicidal behaviour, suicidal ideation, self-injury and depression