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[DOI] [PubMed] [Google Scholar] 47.Wilding J.P.H., Batterham R.L., Calanna S., Davies M., Van Gaal L.F., Lingvay I., McGowan B.M., Rosenstock J., Tran M.T., Wadden T.A., et al

In the real world, it generally involves using doses lower than the established therapeutic amount needed to achieve the intended medical benefit

Gastrointestinal side effects such as nausea, vomiting, diarrhea, or constipation are common across GLP-1 therapies
The addition of GLP-1RA to a usual treatment plan reduced the risk of 42 outcomes

By starting with or maintaining lower doses, providers hope to balance effectiveness with tolerability
PubMed, Gejl, Michael, et al