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As progesterone fluctuates and gradually declines during perimenopause, sleep can become more fragmented and less restorative

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Back pain is not listed among the common or very common adverse reactions in the Summary of Product Characteristics (SmPC) approved by the Medicines and Healthcare products Regulatory Agency (MHRA)

It is unknown whether these differences are simply due to the species or the experimental conditions

For example, the specific reasons people stopped taking the drugs, such as losing health insurance or experiencing a stressful life event, could independently increase their risk for aggressive behavior