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2024;332(1) doi: 10.1001/jama.2024.10333

Slow or stalled weight loss after two months warrants evaluation for medication adherence, injection technique, lifestyle factors, and genetic response patterns

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24 As GLP-1 adoption continues to broaden across approved indications, off-label emerging indications and discretionary off-label prescribing for weight loss in patients without a qualifying comorbidity, the pool of adults with both a GLP-1 prescription and a diagnosis associated with an emerging indication will expand