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What does affect results is chronic inconsistency

In individuals with T2DM, these agents can be used throughout the course of the disease

In a study of older men, restless leg syndrome was associated with a higher mortality rate, even after controlling for a number of other variables.[ref] PLMD is negatively correlated with REM sleep duration and is associated with poorer cognitive function in middle-aged and elderly individuals

Importantly, comorbid T2DM or elevated peripheral IR accelerate disease progression in AD and PD independently of vascular disease, with higher peripheral IR predicting conversion from mild cognitive impairment to AD (12, 13) and faster motor and cognitive decline in PD (14, 15), thereby implicating IR as a modifier of NDD biology rather than a simple comorbidity

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