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The SUSTAIN 7 trial (O'Neil et al., 2018) discovered that individuals with T2DM experienced better clinical outcomes and reduced direct costs when treated with once-weekly Semaglutide at doses of 0.5 and 1 mg compared to Dulaglutide 1.5 mg

On the standard 4-week titration protocol, reaching the 12mg maintenance dose takes approximately 12 weeks

It comes in a pre-filled pen that patients can administer subcutaneously (under the skin)

Characteristics such as unhealthy nutrition habits, sedentary lifestyle as well as visceral obesity, in combination with diabetes, can contribute to other metabolic disorders

GLP-1R agonists effects on cardiovascular events The first pieces of evidence of the potential clinical benefit of GLP-1 agonists have emerged recently, pointing to a decrease of major adverse cardiovascular and cerebrovascular events (MACCE) including stroke, MI, cardiac mortality, acute coronary syndrome, and revascularization procedures

Consider de-addiction therapy with a psychologist