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The ongoing CONFIDENCE trial (NCT05254002) is an international randomised controlled double-blind trial that will directly assess the effects of finerenone plus empagliflozin on albuminuria and characterise the efficacy and safety of this drug combination in the setting of type 2 diabetes

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These cytokines activate the nuclear factor kappa-B (NF-B) signaling pathway,inducing the upregulation of apoptotic proteins and matrix-degrading enzymes, such as metalloproteinases (MMPs), which irreversibly degrade the extracellular matrix (ECM) 6,7