25 semaglutide reddit GOAL! : r/Semaglutide Semaglutide and NT-proBNP in Obesity-Related

2025;11:31.doi.org/10.1186/s40842-025-00245-5

Study findings suggest that GLP-1 drugs can affect your brain in several ways

Key outcomes (surgery vs GLP-1 medicines alone) Compared to medications, surgery offers: 32% lower risk of death (all-cause mortality) 35% lower risk of major cardiovascular events (heart attack, heart failure, stroke) 47% lower risk of serious kidney disease 54% lower risk of diabetes-related eye damage (retinopathy) Greater average 10-year weight loss: ~21.6% vs ~6.8% Bigger A1c reduction: 0.86% vs 0.23% Why Surgery Outperformed GLP-1s in the Real World Adherence: Whether or not youre in a study, if you have weight loss surgery, you are left with a permanent tool to help you lose weight and maintain that loss, providing you follow some basic rules

Why Biological Intervention Matters : According to obesity medicine research published in peer-reviewed journals, traditional behavioral weight loss interventions (diet and exercise alone) typically achieve only 2-4% body weight reduction, with 80-95% of individuals regaining lost weight within 1-5 years due to powerful biological adaptations including: Metabolic rate reduction (adaptive thermogenesis) Hunger hormone dysregulation (increased ghrelin, decreased leptin) Increased appetite and food preoccupation Reduced satiety signaling Enhanced calorie absorption efficiency Decreased energy expenditure during physical activity These biological adaptations explain why "eat less, move more" advice, while physiologically accurate, proves insufficient for most individuals struggling with obesity-their bodies actively resist sustained weight loss through multiple redundant biological mechanisms

Together, these combine into an effective weight management routine

Biochem Biophys Res Commun 196: 141-146, 1993