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There is currently no established causal link between Wegovy (semaglutide) and seizures based on the available clinical trial data and post-marketing surveillance

On the other hand, as last years approvals review noted, by late November 2024, approval recommendations by the EMAs Committee for Medicinal Products for Human Use (CHMP) had already outstripped positive opinions for 2023

In the DURATION 6, HARMONY 7 and LIRALIXI studies, liraglutide 1.8 mg was observed to reduce glycated haemoglobin (HbA 1c ) to a greater extent than exenatide ER 2.0 mg (1.5% vs 1.3%point), albiglutide 50 mg (1.0% vs 0.8%point) and lixisenatide 20 g (1.8% vs 1.2%point), respectively

Here, they demonstrated that, as would be predicted, neither DPP-4I linagliptin or omarigliptin were effective in reducing alcohol consumption in rodents (4)

The studies showed an oral version of semaglutide for Type 2 diabetes, sold under the brand name Rybelsus, didnt slow the progression of memory and thinking problems in older adults

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