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[33, 34, 35, 36] Mechanism: Typically pre-renal, occurring in the setting of volume depletion from GI losses (nausea, vomiting, diarrhea, reduced oral intake) More frequently seen at higher, obesity-level doses Although generally reno-protective long term, post-marketing data describe acute rises in creatinine following days to weeks of significant GI symptoms Risk factors: Underlying chronic kidney disease Concomitant use of ACE inhibitors, ARBs, diuretics, or SGLT2 inhibitors ED Management: IV fluids Hold GLP-1 and contributing medications Usually reversible with supportive care Future Directions GLP-1 receptor agonists are rapidly evolving beyond their original indications in diabetes and obesity

Tirzepatide has helped me learn better eating habits (Protein, Fiber, Healthy Fats), that has lowered blood pressure & improved overall health

Mosenzon O, Wiviott SD, Cahn A, Rozenberg A, Yanuv I, Goodrich EL, et al

They, therefore, have favourable effect on glucose metabolism and lead to significant caloric intake reduction and resultant weight reduction, usually in the vicinity of 3 - 8 kg depending on the dose and agent used

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If a substantial amount of solid material is detected, surgery should be delayed or interventions such as gastric decompression should be considered