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After repeated administration, rats in the short-access paradigm exhibited lower daily and cumulative METH intake than saline controls, with this effect becoming apparent on the second day of treatment and continuing throughout the study, while LIR did not affect METH-taking behavior in the extended-access paradigm

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A progestin injection every 3 months
Concomitant medications At randomisation, on average, individuals in both arms were treated with one glucose-lowering agent