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Description
Other GLP-1R/GIPR co-agonists such as Cpd86 (Eli Lilly), ZP-DI-70 (Zealand) and NN9709/MAR709 (Novo Nordisk/Marcadia) have also been designed and tested in preclinical models of obesity and subsequently advanced to clinical trials (Table 1)
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Trials have demonstrated reductions in major adverse cardiovascular events along with significant weight reduction, particularly with agents such as semaglutide and dulaglutide
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Figure 3AC )
While papillae vallate accommodate hundreds of taste buds, papillae foliatae express around 50 and papillae fungiformis 3 to 5 taste buds [15]
