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doi: 10.1016/S0140-6736(74)91343-9 90 RosenstockJWyshamCFriasJPKanekoSLeeCJFernandez LandoLet al

That is a meaningful safety net

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These microbial-derived signals activate hepatic immune pathways, including toll-like receptor-mediated responses, thereby promoting inflammation, hepatocellular injury, and fibrogenesis

To be able to understand the clinical relevance of the effect, here's the baseline risk of substance use disorder in the control group of persons using SGLT-2 inhibitor: 47 per 1000 persons during 3 years