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Therefore, binding of AT-04 to the target proteins can induce phagocytosis, leading to the clearance of these proteins from the body

GLP-1 receptors are located in brain reward regions including the ventral tegmental area and nucleus accumbens

Eligible participants were youth with newly diagnosed T2D who received GLP-1RA or metformin monotherapy between January 2022 and March 2024

"GLP-1 receptor agonist medications should be started at the lowest dose, and escalated as tolerated or indicated." The case study points out the importance of testing for elevated blood ketones for those with type 1 using a GLP-1

While these adverse effects are uncommon, they can be very serious

Less common but important GLP-1 agonist side effects include increased heart rate in some patients, potential increased risk of gallbladder disease with rapid weight loss, and theoretical concerns about pancreatitis and thyroid C-cell tumors (though these risks remain controversial and may not be clinically significant)