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However, the potential for delaying or preventing the progression of T2DM in patients treated with GIP and GLP-1 remains uncertain, as there is currently no definitive evidence from human studies demonstrating that enhanced incretin activity directly affects -cell mass or alters the progressive loss of insulin secretory capacity in humans
Other side effects, such as diarrhea, vomiting, and constipation, are also relatively common
This has been achieved through techniques such as peptide sequence modification, peptide lipidation, albumin fusion, and Fc fusion

The legitimate medical uses of intravenous infusions may not need a Therapeutic Use Exemption in certain settings (hospital treatment, surgical procedures or clinical investigations)

Additionally, the specific indications and approved uses of each GLP-1 agonist should be considered

How GLP-1 Medications Work in Your Body Let's break down how GLP-1 medications exert their effects: Mimicking the Natural Hormone: GLP-1 medications act like the GLP-1 hormone your body naturally produces after you eat