glp-1 moa Frontiers Frontiers | Mechanisms of action
Description
Rats were pre-dosed with either vehicle or drug at t = 30 and the OGTTs were performed as described previously [9, 12,13,14]

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By binding with GLP-1 receptors, semaglutide suppresses appetite, increases insulin secretion, delays gastric emptying, stimulates glucose-dependent sections of insulin, and reduces food intake to promote weight loss

however, the same effect has not been replicated in large-scale human or primate studies [49]

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