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Together, these findings suggest that Semas ability to engage central appetite-regulating networksparticularly in the hypothalamus, brainstem, and reward centersmakes it a valuable compound for ongoing research into obesity, energy regulation, and neuroendocrine control of eating behavior

Tirzepatide, on the other hand, is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist

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GLP-1 receptor agonists also exert antioxidant, anti-inflammatory, and antifibrotic effects by downregulating pro-inflammatory pathways (e.g., nuclear factor-B), cytokines (e.g., transforming growth factor ), and T-cell proliferation [18]