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By mimicking the incretin hormone GLP-1, medications like liraglutide, exenatide, and dulaglutide enhance glucose-dependent insulin secretion, suppress glucagon, and promote weight loss ( Consequently, numerous randomized controlled trials (RCTs) have investigated the impact of GLP-1 RAs on relevant biomarkers

TRPV1 shows dynamic ionic selectivity during agonist stimulation

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Whilst GLP-1 RAs have a low intrinsic risk of hypoglycaemia due to their glucose-dependent mechanism of action, the risk increases when combined with other glucose-lowering medications

Research progress on molecular mechanism and future perspectives of leonurine

T.et al (2013)