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Common tirzepatide side effects include nausea (usually mild and transient), decreased appetite, and occasional fatigue during dose escalation

Notably, GLP-1RA treatment increased the relative abundance of N, N-dimethyl sphingosine (DMS), an endogenous metabolite derived from sphingosine

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Benefits for People With Type 2 Diabetes People with type 2 diabetes saw two noticeable improvements: Lower blood sugar levels , including meaningful HbA1c reductions Steady weight loss , though typically a little less than non-diabetic participants a pattern also seen with injected GLP-1 receptor agonists The blood sugar improvements reflect how GLP-1 receptor agonists support insulin activity and slow digestion, which may help stabilise glucose throughout the day

10.1523/JNEUROSCI.0115-14.2014 J

doi:10.3233/JPD-181503 216
