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Published in JAMA, the trial followed patients who had already lost an average of 20% of their body weight over 36 weeks on tirzepatide

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Consider eating smaller, more frequent meals rather than three large meals if this pattern better controls hunger

Many users report that fatigue peaks in the first two to four days after each dose increase, then gradually improves over the next one to three weeks as the body adjusts

Protocols and their amendments are publicly accessible in ClinicalTrials.gov under the National Clinical Trial (NCT) identifiers NCT06659744, NCT07088718 and NCT07096063, and in the Open Science Framework (osf.io/38rw9) 43