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Bolling, Kimberly C

On average, one can expect an approximately 5 per cent body weight loss with liraglutide 3mg (SCALE trial), 15 per cent with semaglutide 2.4mg (STEP trials), and 20 to 22 per cent with tirzepatide (SURPASS trials)

Lee JM, Sharifi M, Oshman L, Griauzde DH, Chua KP

A 2mg dose is then (2 / 5) times 100 = 40 units on a U-100 syringe, where 100 units equals exactly 1mL

Bariatric surgery typically gives you a 25% to 35% loss

These pharmacokinetic advantages stem directly from orforglipron's non-peptide nature: as a small molecule, it is inherently resistant to proteolytic degradation in the gastrointestinal tract and does not require the pH-dependent, site-specific absorption mechanisms that constrain peptide-based oral formulations (see our peptide research hub)