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The most commonly reported initial effect in clinical trials is appetite suppression

The black box on Contrave warns that this drug may cause suicidal thinking and behavior in young adults, whether or not patients are taking medicines used to treat depression

It's often prescribed when other oral diabetes medications or injectable insulins haven't provided sufficient blood sugar control

Average weight loss at 68 weeks: Semaglutide (Wegovy): ~15% of total body weight Tirzepatide (Zepbound/Mounjaro): ~2022% Approximately one in three patients loses 20% of body weight

Clinical trials show headache incidence ranges from 3% to 8% depending on dose and individual factors

Combination with psychotherapy should be considered