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The regulation of GLP-1 secretion rhythm by gut microbiota is essential

Semaglutide and Tirzepatide are both GLP-1 receptor agonists, which mimic the action of the natural hormone GLP-1

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Three-carbon disulfide re-bridging chemistry, combined with structure-guided PEGylation originally developed for fibroblast growth factor 2, has now been applied to GLP-1 scaffolds
