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If people stop medication, many are likely to need ongoing nutritional and behavioural support, and health services should anticipate that cardiometabolic benefits may lessen as weight is regained, Spreckley said, adding that this highlights the need for further research into effective, scalable strategies for long-term weight maintenance alongside pharmacotherapy. GLP-1 medications have become widely used in recent years, and more than 15 million Americans are now losing weight with the drugs

No significantly increased risk for thyroid cancer was observed for adults using a GLP-1 receptor agonist compared with those using a DPP-IV inhibitor (HR = 0.81

The Food and Drug Administration expanded the approved use of Wegovy in March to include reducing heart risks for adults who are obese or overweight, allowing Medicare to cover the drug and opening access to Wegovy to about 3 million more Americans

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44 In addition to these indirect effects of GLP-1-based therapies caused by weight loss itself and by related nutritional deficits, it has been hypothesized that direct mechanisms might potentially be associated with structural changes to the face and neck

This is sometimes called a treatment holiday