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That second pathway is actually why adding naltrexonethe other ingredient in Contravemay enhance the effect

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doi: 10.1016/j.fertnstert.2023.07.025 29 SrinivasanDLoftonHF

To test this, we used doxycycline-inducible leptin transgenic mice that ectopically produced leptin from adipocytes to maintain circulating leptin levels during the period of liraglutide injection
