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For these patients, insulin therapy with Tresiba may be the preferred option for glucose control

Simultaneously, sympathetic nervous system activity measured by HR variability and the rate-pressure-product were also elevated, and increases in HR, systolic BP and sympathetic nervous system activity were still observed even with a concomitant L-NMMA-infusion [38]

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For example, a study found that two-thirds of tested expired drugs maintained stability for months or even years after expiration

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This was because the drug has a half-life of 2-4 hours (Holst 2024)