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Jeffers JL, Boyd KL, Parks LJ

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GIPR function in the central nervous system: implications and novel perspectives for GIP-based therapies in treating metabolic disorders

Even when lab values appear normal on medication, many patients still struggle with: Slowed metabolism Insulin resistance Increased fat storage Chronic inflammation Fatigue that limits physical activity These factors create a perfect storm where calorie restriction backfires, muscle mass declines, and weight loss stalls

J Clin Invest (1998) 101(7):142130

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