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Agents in this group include antioxidants (vitamin E), tumor necrosis factor pathway regulators (emricasan, pentoxifylline, ZSP1601), and immune modulators (cenicriviroc, belapectin)

Combining metformin with GLP-1 medications like semaglutide creates a synergistic approach to blood sugar control and sustainable weight loss

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The recently initiated large-sized FLOW trial investigating the effects of semaglutide on hard renal outcomes in patients with DKD will provide clarity whether GLP-1 receptor agonists may reduce the burden of DKD in addition to their other beneficial metabolic and cardiovascular effects.