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Because the prevalence of CVD in the population with T2DM is around 32% [33], at least one fourth of the average patient with T2DM is possible a candidate for the use of the GLP-1RA, or sodium-glucose transporter-2 inhibitors [34], to improve the MACE outcome

118 reported that GLP-1RAs with metformin improved oxidative stress markers, such as IL-6, suggesting a reduction in systemic inflammation

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At another level, GLP-1RAs also improve systemic insulin sensitivity to lower arterial hypertension in T2DM by decreasing the concentration of angiotensin II (Ang II) [41, 42]

Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus