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Central nervous system (CNS): Chronic peripheral 54,66 and central 54 GIPR agonism decreases body weight by reduction in food intake, suggesting a CNS-mediated mechanism

Tirzepatide and testosterone together represent a combination that men with obesity or type 2 diabetes and documented hypogonadism may consider under medical supervision

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The search strategy combined keywords and Medical Subject Headings (MeSH) terms related to: (glucagon-like peptide 1 receptor agonist OR GLP-1RA OR incretins) AND (diabetes mellitus OR diabetes mellitus type 2 OR T2DM OR diabetic kidney disease) AND (albuminuria OR non-albuminuric diabetic kidney disease OR renal outcomes OR renal pathology) AND (precision medicine OR personalized medicine)