dpp-4 inhibitors and glp-1 agonists Frontiers GLP 1 Receptor Agonists and

Acknowledgements This work was supported by research grants from the National Key Research and Development Program of China (2016YFA0100501), the Chinese National 973 Program (2012CB517502), the National Natural Sciences Foundation of China (81400798, 81400767, 81401142, 81270858, and 81570692), and the Beijing Natural Sciences Foundation of China (7163233)

Even medications with lower reported rates still cause this side effect in a subset of patients

doi: 10.3390/ijms231911384 148 LiYXuJLiLBaiLWangYZhangJet al

Its also contraindicated for individuals with a known history of severe stomach problems, such as gastroparesis (delayed stomach emptying), as Tirzepatide can worsen this condition

While these findings suggest that GLP-1s influence biological processes associated with aging, their effects are not uniformly distributed across the hallmarks framework

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