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10.1038/nrendo.2017.91 131 ShiraziR

The odds of developing knee osteoarthritis increase nearly sevenfold with severe obesity
When to Call Your Doctor Most stomach side effects are uncomfortable but manageable

A recent head-to-head clinical trial comparing Wegovy and Zepbound returned similar results
Further studies will be needed to see if tirzepatide drugs, like Zepbound, also increase the risk of blood clots and DVT, which can lead to pulmonary embolisms

Whilst specific interactions have not been documented, theoretical concerns exist for patients taking medications affecting cellular metabolism
