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Background Glucagon-like peptide-1 (GLP-1) induces diuresis and natriuresis

Finally, GLP-1R activation blocked silica-treated macrophage-conditioned media-induced lung fibroblast activation

By exploring human studies and mechanistic insights, this review underscores irisins potential to address global health challenges, such as obesity and type 2 diabetes, while advancing strategies for personalized exercise interventions.

GLP-1 receptor agonists like semaglutide have shown protective effects on kidney function in multiple clinical trials, particularly for people with type 2 diabetes

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