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doi:10.1016/j.peptides.2019.170224 15

Tirzepatide, found in Mounjaro and Zepbound, goes further

Still, more research is needed on GLP-1s and testosterone to fully understand the effects, says Michael Wierschem, MD, urologist and founder of Dallas Men's Health

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This titration phase is designed to reduce the severity of gastrointestinal side effects

A 2024 meta-analysis (Sattar et al., Lancet Diabetes Endocrinol) found that switching from semaglutide to tirzepatide produced an additional 4.2 kg mean weight loss over 40 weeks, even when semaglutide had been titrated to maximum dose