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GLP-1 innovation vector (3): Manufacturing and supply chain After more than a year of severe shortages, both semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound) have recently come off the FDAs shortage listan encouraging signal that supply is stabilizing

158 DDIs with Oral Contraceptives Some GLP-1 RAs and a dual GLP-1/GIP RA altered the exposure of oral contraceptives, implying the potential for clinically significant DDIs (Table 4)

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In these mice, the glucagon response to increasing glucose loads was increased rather than decreased in the -cell GLP-1r KO mice

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Further research is essential to clarify their role and optimize their integration into perioperative management protocols for orthopedic patients