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J Lipid Res (1994) 35(9):153541

found that exenatide increased brain lactate dehydrogenase activity, enhancing anaerobic glucose catabolism in brains of PS1-KI mice (207)

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The insulinotropic effect of GIP is diminished in patients with type-2 diabetes (159) but is restored upon near normalization of glycemia upon 4-week administration of insulin (160)

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There is a substantial decrease in severe adverse cardiovascular events like heart attack and stroke in individuals with T2D who use GLP-1 agonists, regardless of their impact on glucose levels