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E.MillerH.GonzalezA.McDonaldD.et al

Understanding GLP-1 withdrawal symptoms provides insight into what happens when discontinuing therapy, which is relevant for anyone planning an exit strategy from the beginning

The dissociated Epac2 then dimerizes with Rim2 and Piccolo in a Ca 2+ -dependent manner followed by induction of exocytosis of the insulin granules through binding of the Epac2/Rim2/Piccolo complex to Rab3 which is located at the membrane of the insulin granules (Figure 6) [508,511]